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Profiles

Advantageous Systems
Advantageous Systems LLC (ADS) is a start-up medical device company incorporating nanotechnology and biotechnology to revolutionize healthcare by replacing conventional slow, painful, and often times unreliable blood tests with a fast, reliable, and painless point-of-care diagnostic device. The minimally-invasive diagnostic device invented by ADS does not use needles or pinpricks and can diagnose a host of conditions, such as blood glucose levels, HIV/AIDS, other viral and bacterial infectious agents, and certain cancers and autoimmune diseases. Due to its versatility and ease of use, the ADS diagnostic device has the potential to become standard equipment in every hospital and the glucose monitoring device of choice for many diabetics around the globe who dislike the pain or anxiety of pinpricks and needles.

For more information contact:
Adam Stein
Phone: 415-448-6266 • E-mail: adam@advantageoussystems.com

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Anergix LLC Anergix
Anergix LLC is an early phase biotechnology company developing a combined cell/gene therapy treatment for multiple sclerosis, a disease that affects roughly 400,000 Americans and 2.5 million people worldwide. Our therapeutic strategy is to present immune regulatory cells with low doses of the myelin peptide antigen thereby inducing immune tolerance to the suspected myelin antigens thought to cause the autoimmune response. To deliver these myelin peptides, Anergix sequesters proprietary peptide-secreting cells in a small device implanted under the skin. Thus continuous, low dose therapeutic levels of the peptide are generated on a systemic basis – with excellent results in mouse models of the disease. This approach has additional therapeutic applications to other autoimmune diseases.

For more information contact:
Katherine Louie, Ph.D. (CTO) or David Graham (General Manager)
Phone: 626-840-1238 • E-mail: klouie@anergix4ms.com or dgraham@anergix4ms.com

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BCN Biosciences BCN
BCN Biosciences is an early phase biotechnology corporation with core competencies in the oncology drug discovery market. BCN is currently developing novel chemical entities that affect cellular proliferation and cancer. BCN employs technology that can effectively mine novel structures from natural resources, thus maximizing molecular diversity for drug discovery. BCN is also focused on the development of therapeutic agents against a novel epidermal growth factor gene target highly expressed in tumor cells. Our experienced team of drug discovery and oncology experts backs our commitment to developing novel and effective medicines to prevent and treat cancer, one of world's most serious diseases.

For more information contact: Andrew J. Norris Ph.D. or Sudip Chakrabortty
Phone: 310-429-6760 • E-mail: contact@bcnbio.comWebsite: http://www.bcnbio.com

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Cardigant Medical Cardigant Medical
Cardigant Medical Inc a pre-clinical stage biotechnology company focused on the use of biologics and combination biologics and devices for the treatment of acute coronary syndromes ("ACS") and aortic valve stenosis ("AVS". For ACS we are focused on both stabilizing the lipid rich burden present in coronary atheromas as well as addressing the pro-inflammatory environment that can lead to premature plaque rupture. For AVS we are addressing both the calcification of the valve leaflets as well as the lipid buildup up within the leaflet layers. Our research efforts are focused on the use of both drug formulation and design as well as optimized delivery methods that can increase local response and decrease systemic drug exposure. We believe this approach has the potential to reduce drug costs and improve patient safety while still enhancing clinical outcomes.

For more information contact:
Jarett Creed
E-mail: jcreed@cardigant.comy

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Cohbar


A biotechnology company focused on novel mitochondrial-derived peptides and their role in diabetes and aging. The company is committed to developing treatments for Type 2 diabetes mellitus (T2DM), and other age-related diseases, such as atherosclerosis, Alzheimer's disease and cancer.

For more information contact:
Laura Cobb, Ph.D.
E-mail: ljcobb1980@gmail.com

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Deton Corp.


Deton Corp. is focused on delivering solutions to the world's leading causes of death by combining innovations in engineering and medicine. We are specifically focused on lower respiratory diseases such as Tuberculosis and Pneumonia.

For more information

Phone: 310-776-5259Website: http://detoncorp.com/home.htm

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Lanx Chimeric
At Lanx, our mission is to collaborate with spine surgeons who share the view that innovation can improve patient outcomes. We actively engage with surgeons to develop solutions that address current and emerging clinical needs. The result is a product portfolio that is focused on enabling more efficient procedures and improved patient outcomes.

For more information
Website: www.lanx.com

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NeuBiogene, Inc. Neubiogene
NeuBiogene, Inc is a start-up corporation focused on the development of molecular biological techniques and high quality products for research scientists. The unique technologies and products developed by NeuBiogene can help research scientists finish their designed experiments in a cost-efficient and time-saving manner. NeuBiogene’s products and proprietary technologies can be widely applied for DNA, RNA, protein, and histology research. NeuBiogene is also developing new techniques and tools for quick and efficient diagnosis and evaluation of the sensitivity of cancer patients to chemotherapy. Our tools and diagnostics kits can provide clinical doctors an efficient way to decide the best therapy strategy for cancer patients.

For more information contact:
Dr. Edwin Hu, Manager
Phone: 626-927-8477 • E-mail: zhongting@yahoo.com

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Neumedicines, Inc. Neumedicines
Neumedicines Inc. of Pasadena, California, is a preclinical-stage, biopharmaceutical company focused on research and development of novel protein therapeutics that treat and support patients suffering from serious illnesses. The company's lead candidate, HemaMax (recombinant human Interleukin-12, or rhIL-12), is a naturally-occurring signaling molecule that acts at a basic level of the hematopoietic (blood-forming) system by stimulating quiescent stem cells. In preclinical animal models, HemaMax has shown the ability to generate robust and broad hematopoietic recovery in lethally irradiated normal mice as well as in tumor bearing mice treated with radiation and chemotherapy. Neumedicines is currently advancing HemaMax as a treatment for chemotherapy- and radiation-induced thrombocytopenia as well as for Acute Radiation Syndrome.

Because HemaMax possesses both potent hematological and immunological properties, it is uniquely suitable as a hematological adjuvant cancer therapy acting to prevent and alleviate three of the major side effects of cancer treatments, namely anemia, neutropenia and thrombocytopenia.

In 2008, Neumedicines secured a prestigious contract from the Biomedical Agency Radiation Medicine Agency (BARDA) to develop Hemamax for the treatment of the Hematopoietic Syndrome related to Acute Radiation Syndrome (ARS). The Company has also has been awarded a small business grant (STTR) from National Cancer Institute (NCI) for innovative cancer therapies to develop HemaMax as a hematological adjuvant cancer therapy.

For more information contact: Lena A. Basile, Ph.D., J.D., President, Chief Scientific Officer
133 North Altadena Drive, #310, Pasadena, CA 91107
Phone: 818-606-2638 (cell) • 626-844-3810 (office) • E-mail: basile@neumedicines.com

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Ophidion, Inc. Ophidion
Ophidion, Inc., an early-stage private biotechnology company developing a new class of safe and effective drugs targeting some of the most important receptors in the central nervous system. The activity of this target is implicated in cognitive processes (important for the alleviation of symptoms of, as examples, Schizophrenia, ADHD, and Parkinson’s and Alzheimer’s disease), anxiety and depression, pain, as well as many other important medical indications. Ophidion’s licensed approach is to develop drugs that allosterically modulate receptor activity by enhancing or reducing the activity of extracellular, small accessory proteins. Allosteric drugs are predicted to enhance or limit the receptors’ activity while preserving their spatio-temporal activity patterns in the brain, and thereby significantly enhance efficacy and reduce side effects. Ophidion’s approach is an improvement over drugs that continuously activate or suppress these receptors everywhere, thereby causing significant side effects, and that over time cause receptor down-regulation and/or desensitization, and hence loss of efficacy.

Based on the real unmet need for more effective cognitive treatment not only for Alzheimer’s disease patients, but also for the treatment of patients suffering from other dementias, including age-associated memory impairment, mild cognitive impairment, Parkinson’s disease, and vascular dementia; from impaired cognitive abilities in other CNS disorders, such as depression, ADHD, schizophrenia, and autism, and vascular disorders, including hypertension, diabetes, and stroke; and for post-surgical and chemotherapy patients, Ophidion will initially focus on the development of cognitive enhancement drugs. Safer and more effective medication for these population groups would expand the market for cognitive drugs dramatically. Furthermore, the aging population represents additional, enormous growth potential.

For more information contact: Andreas Walz, Ph.D.
E-mail: andreas.walz@ophidionbio.com

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PLC Diagnostics Inc. PLC
PLC Diagnostics, Inc (PLCD) is developing a novel, rapid diagnostic testing platform for sensitive, robust, inexpensive and simple detection of molecular biomarkers. This new platform is based on the company’s novel microarray chip technology that replaces expensive laser scanning with an intersecting grid of 100 mm-wide waveguides embedded in the chip’s substrate. This technology enables real-time quantification of molecular complex formation on the microarray surface without reagent addition or wash steps, thereby significantly reducing assay complexity and cost so that the platform can be used in point-of-care (POC) settings. Our platform offers:

Diagnostics using 5 minutes assay
Immunoassays and nucleic acids
Multiplexing (100 different assays)
Detection in complex matrices – Serum, whole Blood, Urine etc.
Exquisite sensitivity – 1fM or better
Low cost – suitable for Point of Care
Robustness, compactness and ease of operation

For more information contact: Reuven Duer, Ph.D.
E-mail: rduer@plcds.com

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Pyxis Biologix LLC.


A biotech/dietary supplement company, developing plant-based supplements to modulate health and improve living, with a focus on assessing the bioactivity of plant compounds.

For more information contact:

Email: mpanian@pyxisbiologix.com

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Senju USA, Inc. senju
Established in April 2006, Senju USA, Inc is working towards the development of new and exciting products . We're a team of business development and clinical development members who are working together with the same goal in sight---better products for ophthalmic patients.

For more information contact:

Email: contact@senju-usa.com

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Systine, Inc. Systine
Systine provides a fundamentally new etching process and etch processing tool set for precision, damage free etching of semiconductor materials to enhance today’s leading edge 45nm production yields and to meet the industry’s 32 nm and sub-32nm roadmap requirements. Systine’s Low Energy Electron Enhance Etching (LE4) technology utilizes a low energy, dc electron discharge and neutral chemical etching species to drive a highly selective etching reaction that has etched precision device features at dimensions of less than 20nm with a surface finish that approaches atomic smoothness. This represents a significant advance over traditional ion enhanced (dry) etching which relies on momentum transfer by rf field accelerated reactive ions to etch device features. While defining the device features, this momentum transfer inflicts unavoidable material damage that degrades semiconductor device yields and performance. Systine’s patented damage-free LE4 technology breakthrough and the Gradina etching tools based on it will play a major role in helping the semiconductor industry meet the processing demands of extending Moore’s Law to the ultimate limits at an atomic scale and to non-traditional device architectures. Systine is positioned to become a leading supplier in the $4 billion etch equipment market in 2011 and beyond..

For more information contact: AH.P. (Pat) Gillis, Ph.D., CEO, CTO, Co-Founder
E-mail: hpgillis@systineinc.com

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2006 Pasadena Bioscience Collaborative